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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

《医学前沿（英文）》 doi: 10.1007/s11684-023-1043-5

摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

关键词： coronavirus disease 2019     SARS-CoV-2     epidemiology     clinical features    

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Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

《医学前沿（英文）》 2021年 第15卷 第4期   页码 629-637 doi: 10.1007/s11684-020-0825-2

摘要： Cardio-cerebrovascular disease (CCVD) is a major comorbidity of coronavirus disease 2019 (COVID-19). However, the clinical characteristics and outcomes remain unclear. In this study, 102 cases of COVID-19 from January 22, 2020 to March 26, 2020 in Xixi Hospital of Hangzhou were included. Twenty cases had pre-existing CCVD. Results showed that compared with non-CCVD patients, those with CCVD are more likely to develop severe disease (15% versus 1%), and the proportion of pneumonia severity index grade IV was significantly higher (25% versus 3.6%). Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group (90% versus 63.4%). Compared with non-CCVD group, the levels of C-reactive protein, fibrinogen, D-dimer, and serum amyloid-A were higher, whereas the total protein and arterial partial PaO were lower in the CCVD group. Although no statistical difference was observed in the outcomes between groups, CCVD patients received more intensive comprehensive treatment to improve COVID-19 symptoms compared with non-CCVD patients. Integrated Chinese and Western medicine treatments have certain advantages in controlling the severe conversion rate and mortality of COVID-19. In addition, given that COVID-19 patients are usually related to coagulation disorders and thrombosis risk, the application of Chinese medicine in promoting blood circulation and removing stasis should be strengthened.

关键词： COVID-19     cardio-cerebrovascular disease     traditional Chinese medicine     clinical features     clinical therapeutics    

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Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 116-124 doi: 10.1007/s11684-019-0732-6

摘要： Meigs’ syndrome (MS), a rare complication of benign ovarian tumors, is easily misdiagnosed as ovarian cancer (OC). We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018. Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma (OTF) and healthy control groups (all <0.05). However, the serum HE4 levels were lower in the MS group than in the OC group ( <0.001). A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups (all <0.05). However, these variables were higher in the MS group than in the OC group (both <0.05). The neutrophil-to-lymphocyte ratio (NLR) was also significantly lower, whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group (both <0.05). The NLR, platelet-to-lymphocyte ratio, and systemic immune index were significantly higher in the MS group than in the OTF and control groups (all <0.05). The hypoxia-inducible factor-1 mRNA levels were also significantly higher, whereas the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4 T cells obtained preoperatively in a patient with MS than those in patients with OTF, patients with OC, and controls (all <0.05). The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS ( <0.001). These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.

关键词： Meigs’ syndrome     ovarian thecoma-fibroma     NLR (neutrophil to lymphocyte ratio)     CD4+ T cells     glucose metabolism    

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Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient

Zixin Shu, Yana Zhou, Kai Chang, Jifen Liu, Xiaojun Min, Qing Zhang, Jing Sun, Yajuan Xiong, Qunsheng Zou, Qiguang Zheng, Jinghui Ji, Josiah Poon, Baoyan Liu, Xuezhong Zhou, Xiaodong Li

《医学前沿（英文）》 2020年 第14卷 第6期   页码 760-775 doi: 10.1007/s11684-020-0803-8

摘要： Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, = 0.0004 for all cases; 17/77= 22% vs. 7/9= 77.7%, = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment.

关键词： COVID-19     traditional Chinese medicine     clinical features    

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The role of geometrical features in the architectural-structural interaction: Some case studies of the

Maryam ZANDIYEHVAKILI, Isa HOJAT, Mehdi MAHMUDI

《结构与土木工程前沿（英文）》 2019年 第13卷 第3期   页码 716-724 doi: 10.1007/s11709-018-0508-0

摘要： This research aims to enhance the interaction between a structure and its architectural form. Having a qualitative approach, the present work discovers some successfully used geometrical features of the Iranian ancient architecture in terms of the architectural-structural interaction. We define four qualitative criteria for this assessment, i.e., construction-ability, cost effectiveness, participation of the structure in fulfillment of the visual, and functional-semantic needs of the architectural form. For this purpose, two case studies including the Jamé Mosque of Isfahan and the Soltaniyeh building are investigated. The outcomes of this research help designers to not only design efficient structures by adapting non-load bearing elements with the general form of the structure, but also meet concepts such as the unity or perfectionism in the structure.

关键词： architectural-structural interaction     geometrical features     structure     architectural form     Iranian ancient architecture    

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Review on environmental policies in China: Evolvement, features, and evaluation

ZHANG Kunmin, WEN Zongguo, PENG Liying

《环境科学与工程前沿（英文）》 2008年 第2卷 第2期   页码 129-141 doi: 10.1007/s11783-008-0044-6

摘要： This article reviews the development of current environmental policies in China and the great progress made during 1979–2006. Applying lessons learned from industrialized countries to its own situation, China’s environmental policies have the following main features: (1) to explore command and control measures to their fullest extent, (2) to strive to raise funding for environmental protection, (3) to identify who should take accountability for environmental protection; (4) to encourage strategies of “combination of prevention and control” and “integrated utilization”, (5) to embrace openness in the field of environmental policy and early international cooperation. During the past 30 years, China’s environmental policies have evolved and deepened: status expanded the national basic policies of environmental protection by adding a sustainable development strategy, focus changed from pollution control to a combination of pollution control and ecological protection, method changed from end control to source control, scope changed form point source control to watershed and territory pollution control, and management style changed from primarily using executive power to using legal and economic measures. This article introduces how they are evaluated by the international community and provides the prospects of the policies.
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论主战坦克技术特点和发展趋势

王哲荣

《中国工程科学》 2002年 第4卷 第11期   页码 7-11

摘要：

阐述了坦克在战争中的地位，及其将光、机、电、液技术集成为复杂的武器系统，具有强大火力、高度机动与综合防护于一身的性能特点。在分析当前主战坦克存在问题和发展动态的基础上，为适应未来高新技术条件下的作战要求，综述了下一代主战坦克应向低矮化、轻量化、数字化、隐身化的方向发展。

关键词： 主战坦克     技术特点     发展趋势    

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The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

《医学前沿（英文）》 2007年 第1卷 第2期   页码 121-125 doi: 10.1007/s11684-007-0023-5

摘要： Since first described in 1982, intraductal papillary mucinous neoplasm (IPMN) has been the preferred term to describe the proliferation of the pancreatic ductal epithelium. It is totally different from pancreatic carcinoma in epi demiology, histology, pathology and prognosis. According to the site of involvement, IPMNs are classified into three categories, i.e. main duct type, branch duct type, and combined type. Most branch duct IPMNs are benign, whereas the other two types are often malignant. A large branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of adenoma at least. The additional existence of large mural nodules increases the possibility of malignancy in all types. The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs. Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection. On the other hand, asymptomatic branch duct IPMNs without mural nodules can be observed without the need for resection for a considerable period of time. Our review addresses available data, current understanding, controversy, and future directions about IPMNs.

关键词： available     additional existence     necessitate     intraductal papillary     non-invasive    

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Symbolic representation based on trend features for knowledge discovery in long time series

Hong YIN,Shu-qiang YANG,Xiao-qian ZHU,Shao-dong MA,Lu-min ZHANG

《信息与电子工程前沿（英文）》 2015年 第16卷 第9期   页码 744-758 doi: 10.1631/FITEE.1400376

摘要： The symbolic representation of time series has attracted much research interest recently. The high dimensionality typical of the data is challenging, especially as the time series becomes longer. The wide distribution of sensors collecting more and more data exacerbates the problem. Representing a time series effectively is an essential task for decision-making activities such as classification, prediction, and knowledge discovery. In this paper, we propose a new symbolic representation method for long time series based on trend features, called trend feature symbolic approximation (TFSA). The method uses a two-step mechanism to segment long time series rapidly. Unlike some previous symbolic methods, it focuses on retaining most of the trend features and patterns of the original series. A time series is represented by trend symbols, which are also suitable for use in knowledge discovery, such as association rules mining. TFSA provides the lower bounding guarantee. Experimental results show that, compared with some previous methods, it not only has better segmentation efficiency and classification accuracy, but also is applicable for use in knowledge discovery from time series.

关键词： Long time series     Segmentation     Trend features     Symbolic     Knowledge discovery    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 507-527 doi: 10.1007/s11684-020-0814-5

摘要： The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry markets. It has caused infections in humans in China since 2013. Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017. H7N9 with low-pathogenicity dominated in the first four waves, whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave, causing wide concern. Specialists and officials from China and other countries responded quickly, controlled the epidemic well thus far, and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts. Here, we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease. It was summarized and discussed from the perspectives of molecular epidemiology, clinical features, virulence and pathogenesis, receptor binding, T-cell responses, monoclonal antibody development, vaccine development, and disease burden. These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses, such as SARS-CoV-2.

关键词： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Diagnosis of sewer pipe defects on image recognition of multi-features and support vector machine in

Xiangyang Ye, Jian’e Zuo, Ruohan Li, Yajiao Wang, Lili Gan, Zhonghan Yu, Xiaoqing Hu

《环境科学与工程前沿（英文）》 2019年 第13卷 第2期 doi: 10.1007/s11783-019-1102-y

摘要：

An image-recognition-based diagnosis system of pipe defect types was established.

1043 practical pipe images were gathered by CCTV robot in a southern Chinese city.

The overall accuracy of the system is 84% and the highest accuracy is 99.3%.

The accuracy shows positive correlation to the number of training samples.

关键词： Sewer pipe defects     Defect diagnosing     Image recognition     Multi-features extraction     Support vector machine    

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Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 203-207 doi: 10.1007/s11684-011-0138-6

摘要： Traditional Chinese medicine (TCM) is one of the rarely existing ancient traditional medicines that hold systematic theories as well as preventative and therapeutic methods for diseases in practice. From the 1950s, such research methods as mathematics, statistics, and data mining (DM) have been gradually introduced to TCM studies, making it more scientific. Meanwhile, the distinct features of TCM theories and diagnostic-model have constantly challenged the methodology of statistics. This paper introduces the following scientific features of traditional Chinese therapeutics: 1) its goal is to balance the functions and conditions of human body; 2) it emphasizes on holism and individualization; 3) it stresses the longitudinal regulation and evaluation mode, which is a circle of syndrome diagnosis, treatment and evaluation; 4) the interventions of TCM are abundant, compound and natural; and 5) humanistic thought is everywhere. Some statistical problems are raised based on these features. First, complex statistical methods that can analyze subjective indexes and latent variables, multidimensional and multistage data, non-equilibrium designed studies, and longitudinal data are required. Second, comprehensive evaluation on multiple-target mechanism has been brought in by combination treatment. Third, there is a need to analyze how humanity and related cultural factors may influence the effect of interventions. Thus, promoting implemented studies of statistics as well as carrying out the TCM scientific propositions have become the common expectations of both TCM and modern medicine.

关键词： traditional Chinese therapeutics     feature     statistic    

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SMRs – overview, international developments, safety features and the GRS simulation chain

《能源前沿（英文）》 2021年 第15卷 第4期   页码 793-809 doi: 10.1007/s11708-021-0751-2

摘要： The Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) gGmbH as the main technical support organization for the German Federal Government in nuclear safety has been dealing with small modular reactors (SMRs) for about one decade since SMRs are one interesting option for new builds in most countries worldwide which continue to use nuclear energy for commercial electricity production. Currently four different SMR designs are in operation, four in construction, one is licensed, and further 12 are in a licensing process. In this paper, definitions, history, and current developments of SMRs are presented. Subsequently, selected trends of SMR development such as factory fabrication and transport, compactness and modularity, core design, improved core cooling, exclusion of accidents, features for preventing and limiting the impact of severe accidents, economic viability, competitiveness and licensing are discussed. Modeling gaps of the GRS simulation chain programs with a view to applications in nuclear licensing procedures are identified and a strategy for closing these gaps is presented. Finally, selected work on the extension and improvement of the simulation chain and first generic test analyses are presented.

关键词： small modular reactors (SMRs)     history     recent developments     safety aspects     simulation chain of the Gesellschaft für Anlagen- und Reaktorsicherheit (GRS)    

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Accounting for local features of fouling formation on PHE heat transfer surface

Petro Kapustenko, Jiří J. Klemeš, Olga Arsenyeva, Olexandr Matsegora, Oleksandr Vasilenko

《化学科学与工程前沿（英文）》 2018年 第12卷 第4期   页码 619-629 doi: 10.1007/s11705-018-1736-5

摘要： The fouling phenomena can create significant operational problems in the industry by deteriorating heat recuperation, especially in heat exchangers with enhanced heat transfer. For a correct prediction of fouling development, the reliable fouling models must be used. The analysis of existing fouling models is presented. The chemical reaction and transport model developed earlier for a description of fouling on intensified heat transfer surfaces is used for modeling of plate heat exchanger (PHE) subjected to fouling. The mathematical model consists of a system of differential and algebraic equations. The integration of it is performed by finite difference method with developed software for personal computer. For countercurrent streams arrangement in PHE the solution of two-point boundary problem is realized on every time step. It enables to estimate local parameters of heat transfer process with fouling formation and its development in time with the growth of deposited fouling layer. Two examples of model application in cases of PHEs working at sugar factory and in district heating network are presented. The comparison with experimental data confirmed the model validity and the possibility of its application to determine the performance of PHE subjected to fouling.

关键词： heat transfer     fouling     plate heat exchanger     mathematical model    

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利用两个自适应特征改进实体链接 Research Article

张鸿彬,陈权,张伟文

《信息与电子工程前沿（英文）》 2022年 第23卷 第11期   页码 1620-1630 doi: 10.1631/FITEE.2100495

摘要：

实体链接是自然语言处理中的一项基本任务。现有的基于神经网络的系统更多地关注全局模型的构建，而忽略了局部模型中潜在的语义信息和有效实体类型信息的获取。本文提出两个自适应特征，其中第一个自适应特征使得局部和全局模型能够捕获潜在信息，第二个自适应特征能够描述实体类型嵌入的有效信息。这些自适应特征可以很自然地协同工作来处理一些不确定的实体类型信息。实验结果表明，我们的实体链接系统在AIDA-B和MSNBC数据集上取得了最佳的性能，并在域外数据集上达到了最佳的平均性能。这些结果表明，所提出的自适应特征能够基于其自身不同的上下文来捕获有利于实体链接的信息。

关键词： 实体链接；局部模型；全局模型；自适应特征；实体类型    

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标题 作者 时间 类型 操作

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

期刊论文

Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

期刊论文

Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

期刊论文

Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient

Zixin Shu, Yana Zhou, Kai Chang, Jifen Liu, Xiaojun Min, Qing Zhang, Jing Sun, Yajuan Xiong, Qunsheng Zou, Qiguang Zheng, Jinghui Ji, Josiah Poon, Baoyan Liu, Xuezhong Zhou, Xiaodong Li

期刊论文

The role of geometrical features in the architectural-structural interaction: Some case studies of the

Maryam ZANDIYEHVAKILI, Isa HOJAT, Mehdi MAHMUDI

期刊论文

Review on environmental policies in China: Evolvement, features, and evaluation

ZHANG Kunmin, WEN Zongguo, PENG Liying

期刊论文

论主战坦克技术特点和发展趋势

王哲荣

期刊论文

The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

期刊论文

Symbolic representation based on trend features for knowledge discovery in long time series

Hong YIN,Shu-qiang YANG,Xiao-qian ZHU,Shao-dong MA,Lu-min ZHANG

期刊论文

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

期刊论文

Diagnosis of sewer pipe defects on image recognition of multi-features and support vector machine in

Xiangyang Ye, Jian’e Zuo, Ruohan Li, Yajiao Wang, Lili Gan, Zhonghan Yu, Xiaoqing Hu

期刊论文

Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

期刊论文

SMRs – overview, international developments, safety features and the GRS simulation chain

期刊论文

Accounting for local features of fouling formation on PHE heat transfer surface

Petro Kapustenko, Jiří J. Klemeš, Olga Arsenyeva, Olexandr Matsegora, Oleksandr Vasilenko

期刊论文

利用两个自适应特征改进实体链接

张鸿彬,陈权,张伟文

期刊论文